Mitochondrial reactive oxygen species: which ROS signals cardioprotection?
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چکیده
منابع مشابه
Mitochondrial reactive oxygen species: which ROS signals cardioprotection?
Mitochondria are the major effectors of cardioprotection by procedures that open the mitochondrial ATP-sensitive potassium channel (mitoKATP), including ischemic and pharmacological preconditioning. MitoKATP opening leads to increased reactive oxygen species (ROS), which then activate a mitoKATP-associated PKCε, which phosphorylates mitoKATP and leaves it in a persistent open state (Costa AD, G...
متن کامل1 2 Mitochondrial Reactive Oxygen Species — Which ROS Signals Cardioprotection ? 3 4
30 Mitochondria are the major effectors of cardioprotection by procedures that open the 31 mitochondrial ATP-sensitive potassium channel (mitoKATP), including ischemic and 32 pharmacological preconditioning. MitoKATP opening leads to increased reactive oxygen 33 species (ROS), which then activate a mitoKATP-associated PKCε, which phosphorylates 34 mitoKATP and leaves it in a persistent open sta...
متن کاملCALL FOR PAPERS Mitochondria in Cardiovascular Physiology and Disease Mitochondrial reactive oxygen species: which ROS signals cardioprotection?
Garlid AO, Jaburek M, Jacobs JP, Garlid KD. Mitochondrial reactive oxygen species: which ROS signals cardioprotection? Am J Physiol Heart Circ Physiol 305: H960–H968, 2013. First published August 2, 2013; doi:10.1152/ajpheart.00858.2012.—Mitochondria are the major effectors of cardioprotection by procedures that open the mitochondrial ATP-sensitive potassium channel (mitoKATP), including ischem...
متن کاملMitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.
Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of potentially damaging levels of reactive oxygen species (ROS), Ca(2+), etc., which must be normalized. Evidence suggests that brief mitochondrial permeability transition pore (mPTP) openings play an important physiological role maintaining healthy mitochondria homeostasis. Adaptive and maladaptive responses to r...
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We sought to understand the relationship between reactive oxygen species (ROS) and the mitochondrial permeability transition (MPT) in cardiac myocytes based on the observation of increased ROS production at sites of spontaneously deenergized mitochondria. We devised a new model enabling incremental ROS accumulation in individual mitochondria in isolated cardiac myocytes via photoactivation of t...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2013
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00858.2012